MERCK SHARP & DOHME CORP.;MEMORIAL SLOAN KETTERING CANCER CENTER;ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
发明人:
PALESE, PETER,GARCIA-SASTRE, ADOLFO,ZAMARIN, DMITRIY,SADEKOVA, SVETLANA,ALTURA, RACHEL ALLISON,PHAN, UYEN,HAINES, BRIAN B.,WOLCHOK, JEDD D.
申请号：
CA3061770
公开号：
CA3061770A1
申请日:
2018.05.11
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Described herein are chimeric Newcastle disease viruses comprising a packagedgenome comprising a transgene encodinginterleukin-12. The chimeric Newcastle disease viruses and compositionsthereof are useful in combination with an antagonist ofprogrammed cell death protein 1 ("PD-1") or a ligand thereof in the treatmentof cancer. In particular, described herein are methods fortreating cancer comprising administering the chimeric Newcastle diseaseviruses in combination with an antagonist of PD-1 or a ligandthereof, wherein the chimeric Newcastle disease virus comprises a packagedgenome comprising a transgene encoding interleukin-12.
