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ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ЛЕЧЕНИЯ ГИПЕРТЕНЗИИ
专利权人:
ТСХ БИОФАРМ КОРПОРЕЙШН; ЛИМИТЕД (CN)
发明人:
ЧЭНЬ Чжао-Вэнь (CN),ВАН Си-Це (CN),ЧЖУАН Синь-И (CN)
申请号:
RU2012151051/15
公开号:
RU2012151051A
申请日:
2011.04.29
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method of treating hypertension or a symptom caused by it in a subject comprising administering to the subject a pharmaceutical composition comprising an effective amount of dextromethorphan and pharmaceutically acceptable nositel.2. The method of claim 1, wherein the effective amount comprises from about 0.1 mg / day to about 500 mg / day dekstrometorfana.3. The method of claim 1, wherein the pharmaceutical composition is administered by intravenous infusion, by transdermal delivery or orally as a tablet or kapsuly.4. A method according to claim 1, further comprising administering to the subject an inhibitor of CYP2D6, which is effective for extending the half-life of dextromethorphan at subekta.5. A pharmaceutical composition for treating hypertension caused by it or symptom in a subject, comprising an effective amount of dextromethorphan, the effective amount of calcium channel blocker and a pharmaceutically acceptable nositel.6. The pharmaceutical composition of claim 5 wherein calcium channel blocker is selected from the group consisting of amlodipine, bepridil, klentiazema, diltiazem, fendiline, gallopamil, mibefradil, prenylamine, semotiadila, terodilina, verapamil, aranidipine, barnidipine, benidipine, cilnidipine, efonidipine, elgodipine , felodipine, isradipine, lacidipine, lercanidipine, manidipine, nicardipine, nifedipine, nilvadipine, nimodipine, nisoldipine, nitrendipine, cinnarizine, flunarizine, lidoflazina, lomerizina, bencyclane, etafenona, perhexiline and flus irilena.7. A pharmaceutical composition according to claim 5, comprising from about 0.1 mg to about 500 mg of dextromethorphan and from about 0.01 mg to about 100 mg of a calcium channel blocker on medication1. Способ лечения гипертензии или обусловленного ею симптома у субъекта, включающий введение субъекту фармацевтической композиции, содержащей эффективное количество декстрометорфана и фармацевтически приемлемый носитель.2. Способ по п.1, где эффективное количество включает от пример
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