Joseph G. Sodroski,Navid Madani,Arne Schön,Judith M. LaLonde,Joel R. Courter,Takahiro Soeta,Danny Ng,Ernesto Freire,Amos B. Smith, III,Amy M. Princiotto,Matthew Le-Khac,Wayne A. Hendrickson
申请号：
US13128549
公开号：
US09776963B2
申请日:
2009.11.10
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention provides for compounds of formula I: wherein Z is absent or (CRARB)nW each RA and RB is independently (i) H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, haloalkyl, each of which may be optionally substituted (ii) OH, ORc, NH2, NHRc, NRcRc, SH, S(O)mRc or (iii) RA and RB together form C(O) W is absent, C(O), C(O)O, C(O)NRcRc, O, S(O)m, or NRcRc Y is an optionally substituted heterocyclic, optionally substituted heteroaryl, optionally substituted cycloalkyl, optionally substituted aryl, or NRXRY wherein Rx and Ry are each independently H, alkyl or aryl X1 is selected from the group consisting of halogen, methyl, and hydroxyl X2 is a halogen each Rc is independently alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, or heteroaralkyl, each of which may be optionally substituted m is O, 1, or 2 and n is 1, 2, 3, 4, 5, or 6 and pharmaceutically acceptable salts thereof.
