您的位置: 首页 > 农业专利 > 详情页

תוצרים גנטיים המבוטאים שונה בגידולים והשימוש בהם
专利权人:
GANYMED PHARMACEUTICALS AG
发明人:
申请号:
IL23129414
公开号:
IL231294D0
申请日:
2014.03.04
申请国别(地区):
IL
年份:
2014
代理人:
摘要:
Pharmaceutical composition (A) comprises an agent (I) that inhibits the expression or activity of a tumor-associated antigen (TAg) that is encoded by a nucleic acid (NA) that: (a) is any of 22 specified sequences (reproduced) or their fragments or derivatives; (b) hybridizes to (a) under stringent conditions; (c) is a degenerate variant of (a) or (b); or (d) is the complement of (a)-(c). Independent claims are also included for: (1) pharmaceutical composition (A1) comprising an agent (Ia) with tumor-inhibiting activity that is selective for cells showing (abnormal) expression of TAg; (2) pharmaceutical composition (A2) comprising an agent (Ib) that selectively increases the amount of complex formed between an HLA molecule and TAg, or its fragments; (3) pharmaceutical composition (A3) containing one or more of TAg (or its fragments), NA that encodes TAg, antibodies (Ab) that bind TAg, antisense nucleic acids that hybridize specifically to NA, and host cells that express TAg; (4) diagnosing a disease associated with (abnormal) expression of TAg; (5) determining regression, progression or onset of a disease associated with (abnormal) expression of TAg; (6) treating a disease associated with (abnormal) expression of TAg; (7) treatment, diagnosis or monitoring of a disease associated with (abnormal) e xpression of TAg; (8) inhibiting development of cancer by administering any of A1-A3; (9) new nucleic acid (NA1) that is any of 3 specified sequences (reproduced; included within NA), their fragments or derivatives, degenerate variants, complements or sequences that hybridize to them; (10) nucleic acid (NA2) that encodes a protein/polypeptide having any of 4 amino acid (aa) sequences reproduced, or their fragments or derivatives; (11) recombinant DNA or RNA (NA3) that comprises NA1 or NA2; (12) host cells that contain NA1-NA3; (13) protein or polypeptide (P) encoded by NA1 or containing the aa sequences of (10); (14) immunogenic fragments of (P) and fragments that can bind
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充