HENRY, WILLIAM,WOLF-GARRAWAY, RICHARD,MAYO, JOHN CHARLES,EARL, MICHAEL JAMES
申请号：
CA2869993
公开号：
CA2869993A1
申请日:
2013.04.16
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Methods and dosage formulations are provided for subcutaneous administration in which therapeutic agents are modified to increase the hydrophilicity and molecular dimensions in relation to the native state of the therapeutic agent, in which the Cmax:Caverage ratio is lower than the Cmax:Caverage ratio of the agent when delivered intravenously.
