A system (410) for mixing or reconstituting a drug contained in a first container (412) with a diluent or fluid contained in a second container (414), The second container has a port docking assembly (418) for engaging the first container. The first container is rotatable and axially slidable within the port docking assembly. The port docking assembly has an actuator (484) to urge a stopper (428) fluidly sealing the first container into the interior of the first container. The port docking assembly further includes a movable plug (489) constructed to fluidly seal the second container in a first, docked position and to provide access to the interior of the second container in a second, activated position, whereby fluid communication between the first and second containers is provided when the first and second containers are in the second, activated position.
