OLAF PANKNIN,STEFAN BÄURLE,SVEN RING,WOLFGANG SCHWEDE,WILHELM BONE,KATRIN NOWAK-REPPEL,ECKHARD BENDER,REINHARD NUBBEMEYER,MARK JEAN GNOTH
申请号：
TN2014000306
公开号：
TN2014000306A1
申请日:
2014.07.15
申请国别(地区):
TN
年份:
2015
代理人:
摘要：
Spiroindoline derivatives, process for their preparation and pharmaceutical compositions thereof, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially sex-hormone-related diseases in both men and women, in particularly those selded from the group of endometriosis, uterine fibroids, polycystic ovarian disease, hirsutism, precocious puberty, gonadal steroid-dependent neoplasia such as cancers of the prostate, breast and ovary, gonadotrope pituitary adenomas, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hypertrophy, contraception and infertility (e.g., assisted reprodudive therapy such as in vitro fertilization). The present application relates in particular to spiroindoline derivatives as gonadotropin-releasing hormone (GnRH) receptor antagonists.
