ANTI-NOTCH1 NRR ANTIBODIES AND METHODS USING SAME

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专利权人:

GENENTECH; INC.

发明人:

SIEBEL, CHRISTIAN, W

申请号：

NZ58130308

公开号：

NZ581303A

申请日:

2008.06.03

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

Provided is an isolated anti-Notch1 negative regulatory region (NRR) antibody, wherein said antibody binds a Notch1 NRR with a Kd of 1 x 10-7 or stronger and wherein said antibody, when bound to said Notch1 NRR, decreases Notch1 signalling. The antibodies can be used to treat various cancers.

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