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CRISTAUX D'UN SOLVATE DE DERIVE D'ACIDE QUINOLINECARBOXYLIQUE
专利权人:
NIPPON SHINYAKU CO.; LTD.
发明人:
AKAI, JUN,NISHIDA, HIROSHI
申请号:
CA2523854
公开号:
CA2523854C
申请日:
2004.04.28
申请国别(地区):
CA
年份:
2012
代理人:
摘要:
A main object is to provide a crystal of 6-fluoro-1-methyl-7-[4-(5-methyl-2-oxo-1,3-dioxolen-4-yl)-methyl-1-piperazinyl]-4-oxo-4H-[1,3]thiazeto [3,2-a]quinoline-3-carboxylic acid acetonitrile solvate (Compound B) which is anintermediate for producing preferentially the type III crystalof 6-fluoro-1-methyl-7-[4-(5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl-1-piperazinyl]-4-oxo-4H-[1,3]-thiazeto [3,2-a]quinoline-3-carboxylic acid (Compound A).A crystal of Compound B can be preferentiallyprecipitated by controlling the supersaturation concentrationin crystalization using acetonitrile as a solvent.Subsequently, the type III crystal of Compound A can be producedby performing desolvation of the crystal.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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