GLAXOSMITHKLINE BIOLOGICALS SA;LIQUIDIA TECHNOLOGIES, INC.
发明人:
申请号：
ARP170100554
公开号：
AR107813A1
申请日:
2017.03.06
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
Drug release particles can prevent the interaction between particles in the water environment where such particles exist and the biological activity load in the ingredients. The particles are very sensitive to pH, so when the critical pH level is exceeded, the biological activity load can enter the surrounding environment. Therefore, these particles help to store the biologically active load stably in the water component, which contains components that would otherwise have harmful interaction with the load,In addition, ingredients, including these particles, and procedures for preparing and using these particles and ingredients are provided to mitigate biological effects on animal bodies, such as the human body. 1. Characteristic 1: multiple pH sensitive drug release particles, containing biological activity load in the mother,When these particles exist in the water environment, their pH value is higher than that in the water environment, and in the water environment, these particles are generated and maintained before being activated, then these particles are activated to release the load. Claim 2: multiple particles in accordance with claim 1, In the water environment, the matrix is insoluble in the sub physical pH value, and the matrix can be dissolved in the physical activation pH value in the water environment. Claim 19: according to any one of the requirements in 1-18, the particle diversity,How beautiful the matrix is. 19. Claim 23: a plurality of particles according to any one of claims 19-22, wherein a plurality of particles include a copolymer (polydicarboxylic acid - polytricarboxylic acid) (pmma-co-pmaa copolymer)；1. Poli (glutamate) - co poli (lysine)；hetero- u homopoli (amino cidos) zwitteri nico carboximetil quitosano ftalato de hipromelosa acetato succinato de hipromelosa o un copol mero de acrilato representado por la f rmula general (1) en la que R representa hidr geno o metilo R representa hidr geno o metilo y This load includes an oligopoly / pol
