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Process for the preparation of 4 - amino - 5 - fluoro - picolinatos Halo 3 - 6 - (substituted)
专利权人:
DOW AGROSCIENCES LLC
发明人:
申请号:
ARP120100233
公开号:
AR085021A1
申请日:
2012.01.24
申请国别(地区):
AR
年份:
2013
代理人:
摘要:
1. Claim 1: a process of 4-amine-5-fluoro-3-hal O-6 (alternative) - picolinato formula (1), wherein w represents Cl, Br or I; R represents C1-4 tar, cyclopropene, c2-4 or phenyl, which is replaced by 1 to 4 selected substitutes; independent of halogen, C1-4 tar, C1-4 halo tar, C1-4 halo-4, C1-4 or C1-4 halogenated alcoxi; R1 refers to pitch not replaced or replaced by C1-12 or c7-11; it consists of the following steps: (a) fluorinated 4.5.6-trichloropyridine alcohol (a), wherein R1 is previously defined;(b) 4.5.6-trifluoropylhydrazine carbamate (b) and ammonia formula (b) amino oxidation 4.5.6-trifluoropylhydrazine to produce 4-amino5.6-difluoropropylformate (c), wherein R1 is previously defined; (c) To exchange 4-amino-5.6-difluoropicolinato grade 6 fluoride substitute with iodine, bromine or chlorine substitute, and to process with iodine, bromine or chlorine source to produce 4-amino-5-fluoro-6-haloxycyclopinato (d), where X represents Cl, Br or I, R1 is previously defined;(d) 4-amino-5-fluoro-6-halocyclopolinato (d) type halogenation, with a halogen source to produce 4-amine-3, 6-dihydro-5-fluo-opolinato (E) type 4-amine-3, 6-dihydro-5-fluo-opolinato (E), where W and x represent previously defined Cl, Br or I, R1; and (E) 4-amino-3 coupling, 6-dihalo-5-formula (E) fluoroacrylic acid, its metal compound is arilo, tar or alkali in formula: r-met, where R is previously defined, met represents halogenated Zn, zn-r, tri - (C1-4 tar) tin, copper or B (or2) (or3),R2 and R3 are independent,Hydrogen, C1-4 tar, or, when they're taken together, Production of 4-amino-5-fluoro-3-halo-6-picolonat (replaced) in formula (1) 4-amine-5-halo-6-picolonat (replaced) group of ethylene or propylene: a compound selected from that group, including: (a) a formula compound (2), wherein R represents C1-4 tar, Cyclopentanol, alquenilo c2-4 or Phenyl is replaced by independently selected halogen, C1-4 tar, C1-4 halide, C1-4 halogen or C1-4 halogen and R1 substitute, representing C1-12 tar or
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