A specimen sample collection system includes a handle having opposing first and second ends, and a sufficiency indicator coupled to the handle, wherein the handle second end and sufficiency indicator form a cavity adapted to receive a sample collection pad； a sample collection pad having opposing ends, the sample collection pad partially contained within and extending from the handle second end and in contact with the sufficiency indicator, the sample collection pad having a cylindrical cross section； and, a pad compression tube having a first open end to go over the sample collection pad and second end of the handle, an opposing second end, an interior surface extending therebetween, and at least outlet port proximal to the pad compression tube second end and in fluid communication with the pad compression tube interior. The system may include wherein the sufficiency indicator is a light pipe or other indicating element, providing visual, aural or haptic indication of sufficient sample volume. The system may include wherein the sufficiency indicator includes longitudinal channels extending along the interior surface in contact with the sample collection pad to provide a path for displace air. The system may include a sealing member to seal against a pad compression tube and to engage the specimen collection pad. The system may include one or more collection tubes attachable to one or more of the pad compression tube outlet ports. The system may include ergonomic features for the handle and pad compression tube. The system may include a specimen collection pad having a full cross section portion and a reduced cross section portion, including a shoulder to engage a sealing member and an angled surface to conform to the interior surface of a light pipe sufficiency indicator. The system may include one or more in-line filters adjacent the pad compression tube outlet ports. The system may include additional features as described herein.
