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항균성 1H-인다졸 및 1H-인돌 유도체
专利权人:
액테리온 파마슈티칼 리미티드
发明人:
위브슈웨를랭 크리스띠앙,오샬라 에띠엔,스페클랭 장-뤽,쉬리베 장-필리쁘,미르 아젤리,샤뿌 가엘,고뱅 장-크리스토쁘
申请号:
KR1020167019669
公开号:
KR1020160098503A
申请日:
2014.12.18
申请国别(地区):
KR
年份:
2016
代理人:
摘要:
The present invention relates to antimicrobial compounds and their salts of the formula (I): [Wherein, X is N or CH R 1 is H or halogen R 2 is M or alkynyloxy group R 3 is H or halogen M M is indicated for A and M B is one of the groups: (In the formula, A is a bond, CH 2 CH 2 , CH = CH or C C, and R 1A is H or halogen R 2A is H, alkoxy or halogen R 3A is H, alkoxy, hydroxy, alkoxy, alkoxyalkoxy, thioalkoxy, trifluoromethoxy, amino, hydroxyl hydroxyalkyl, 2-hydroxy-acetamido-1-amino-cyclopropyl, 1-hydroxymethyl-cyclopropyl prop-1-day, 1-((phosphono) methyl) cyclopropyl, 1-(((dimethyl glycyl) oxy) methyl) cyclopropyl, trans- 2-hydroxymethyl-bicyclo prop-1-il, 1,2-dihydroxyethyl, 3-hydroxy-oxetane-3 -yl, 3-(hydroxyalkyl) oxetane-3-yl, 3-amino-oxetane-3-yl, 3-hydroxyl City ethane-3-yl, morpholin-4-yl-alkoxy, morpholin-4 -yl-alkyl, oxazol-2-yl, or [1,2,3] triazol-2-yl, and R 1B is a hydroxy-alkyl, di-hydroxy alkyl, amino alkyl, 1 -hydroxymethyl-bicyclo prop-1-day, 1-amino-methyl-bicyclo prop-1-il, trans-2-hydroxymethyl-bicyclo prop-1, 3-hydroxymethyl oxetane-3 -yl, 3-hydroxyl City ethane-3-yl, 1-(2-hydroxy-acetyl) azetidin-3-yl, 1-(2-amino-acetyl) azetidin-3-yl, 1-glycyl Ajay tidin-3-yl, 1-(2-amino-2-methyl propanoyl) Kinase tidin-3-yl, 3-(2-amino acetamido) cyclopentyl, trans-(cis-3,4-di hydroxyphenyl) pent cyclo-1-1 or 3-hydroxy [1,1,1] methyl pentane bicycle-1-discretionary)]본 발명은 하기 화학식 (I) 의 항균성 화합물 및 이의 염에 관한 것이다:[식 중, X 는 N 또는 CH 이고 R1 는 H 또는 할로겐이고 R2 는 알키닐옥시 또는 M 기이고 R3 는 H 또는 할로겐이고 M 는 하기에 나타낸 MA 및MB 기 중 하나임:(식 중, A 는 결합, CH2CH2, CH=CH 또는 C≡C 이고 R1A 는 H 또는 할로겐이고 R2A 는 H, 알콕시 또는 할로겐이고 R3A 는 H, 알콕시, 히드록시알콕시, 알콕시알콕시, 티오알콕시, 트리플루오로메톡시, 아미노, 히드록시알킬, 2-히드록시아세트아미도, 1-아미노시클로프로필, 1-히드록시메틸-시클로프로프-1-일, 1-((포스포노옥시)메틸)시클로프로필, 1-(((디메틸글리실)옥시)메틸)시클로프로필, 트랜스-2-히드록시메틸-시클로프로프-1-일, 1,2-디히드록시에틸, 3-히드록시옥세탄-3-일, 3-(히드록시알킬)옥세탄-3-일, 3-아미노옥세탄-3-일, 3-히드록시티에탄-3-일, 모르폴린-4-일알콕시, 모르폴린-4-일-알킬, 옥사졸-2-일 또는 [1,2,3]트리아졸-2-일이고 R1B 는 히드록시알킬,
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