#$%^&*AU2015238869A120151029.pdf#####H: rec Interwoven NRPortbl DCC REC 8609982 Ldocx-8/10/2015 ABSTRACT Of the cytopathic retroviruses that affect mammals, including HIV-J, many selectively infect CD4+ T cells and cause immuno suppressive syndromes. These diseases destroy both the thymus and the small and large intestines, after infecting and killing Tlineage cells in both tissues. A mutant of the murine leukemia retrovirus MoMuL V -TB, called tsl, causes this syndrome in susceptible strains of mice. In FVB/N strain mice that are infected at birth, thymic atrophy, CD4+ T cell loss, intestinal collapse, body wasting, and death occur by 30-40 days postinfection (dpi). Apoptosis of tsl -infected T-lineage cells, in the thymus, peripheral lymphoid system and intestines is caused by accumulation of the tsl mutant viral envelope preprotein gPr80env which is inefficiently cleaved into the mature viral proteins gp70 and PrP 15E.WO 2010/096686 PCI/U S2010/024785 1/16 DRAWINGS .'.m V#' .. .... .... ... On b <； IN Fig I'"~w.
