LEDOUSSAL BENOIT,GOURDEL MARIE EDITH,RENAUD EMILIE,PIERRES CAMINIE,KEBSI ADEL
申请号：
CO11043787
公开号：
CO6382121A2
申请日:
2011.04.08
申请国别(地区):
CO
年份:
2012
代理人:
摘要：
The Invention relates to Heterocyclic nitrogen compounds of formula (i): in which R1 represents Hydrogen (CH2) M - NH2, - NH (CH2) M - (C1 - C6) ALC M - N - (CH2) (C1 - C6) alc2, - M - NH (CH2) - C (NH) NH2 (CH2) - M or - NH - ch = NH, M is equal to 1 or 2； R2 and R3 together form a nitrogen heterocycle as ar Om u00e1tico with 5 vertices containing 1, 2 or 3 nitrogen Atoms.Replaced by a nitrogen Atom in R4, R4 represents Hydrogen, Lac (C1 - C6) or a Chain of formula: (a) - N - (NH) or - (CH2) P - (CHR) Q R 'represents'； c = c = o, NH, or SO2； R' represents Hydrogen or carboxyl； R represents Hydrogen, NH2, NH (C1 - C6), Lac (C1 - C6) aic2, CONH2, with (C1 - C6) with ALC (C1 - C6) LC2, or a saturated Heterocycles with 5 or 6 vertices containing 1 or 2 nitrogens and, where appropriate,An oxygen or sulfur, fixed to the chain through a nitrogen or carbon and eventually replaced by Lac (C1 - C6), N, o and q represent 0 OR 1 and q represents an integer of 0 to 4； R5 represents oso3h, ocfco2h or ocf2co2h； r1 is Hydrogen, - (CH2) M - NH2, - (CH2) MNH (C1 - C6) or - (CH2) ALC M - N (C1 - C6) Alc2 while R4 is Hydrogen, - (C1 - C6) Lac - (c = o) - (CH2) (0 - 5) - NH2,- (c = o) - (CH2) (0 - 5) - NH (C1 - C6) ALC or N - (c = o) - (CH2) (0 - 5) - N (C1 - C6) alc2 and R5 is a Group oso3h or when R4 has all values R 'mentioned above, with the exception of the heterocycle, and N, o, P and Q can not all be equal to Zero except when r is Hydrogen or CONH2, with (C1 - C6 alc2, (c) 1 - alc2, C6)Or heterocycle； in free form and in the form of zwitterions and bases and salts with pharmaceutically acceptable organic or mineral acids, their Preparation and their use as Antibacterial Drugs.La invención se refiere a compuestos heterocíclicos nitrogenados de fórmula (I):en la que:R1 representa hidrógeno, (CH2)m-NH2, -(CH2)m-NH(C1-C6)alc, -(CH2)m-N(C1-C6)alc2, -(CH2)m-NH-C(NH)NH2 o -(CH2)m-NH-CH=NH, m es igual a 1 ó 2；R2 y R3 forman juntos un heterociclo nitrogenado de carácter aromático con 5 v
