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LIPOSOMALLY ENCAPSULATED REDUCED GLUTATHIONE FOR MANAGEMENT OF CANCER AND DISRUPTION OF CANCER ENERGY CYCLES
专利权人:
GUILFORD; Frederick; Timothy
发明人:
GUILFORD, Frederick, Timothy
申请号:
USUS2013/020422
公开号:
WO2013/109421A1
申请日:
2013.01.05
申请国别(地区):
WO
年份:
2013
代理人:
摘要:
This invention proposes an agent to block the "fuel supply" that energizes cancer cell growth by protecting surrounding cells to the cancer, particularly stromal fibroblast cells. The invention disables the products of surrounding cells useable for energy conversion by the cancer cell thereby crippling the cell and disabling its growth process. This application describes the use of a formulation of liposomally encapsulated glutathione that is preferably used orally to increase the level of glutathione in tissues in order to prevent and reverse the metabolic changes in cells that results in the formation of the metabolic fuel that supports cancer cells and to prevent the oxidative stress that damages normal support cells such as fibroblasts and can prevent and reverse these cells from the steps of autophagy and mitophagy that results in the cells decreasing the normal mitochondrial production of ATP for energy and resorting to the use of aerobic glycolysis for energy production. The use of oral liposomally encapsulated glutathione will maintain the presence and normal function of caveolin in fibroblast and other cells, thus preventing their conversion to autophagic tumor stromal cells. By stopping the formation of autophagic cells, the production of the metabolic fuel needed by cancer cells is stopped, which results in the death of the cancer cells. Compositions using liposomally encapsulated glutathione and other compounds that enhance the favorable effects of liposomal glutathione on cancer disease are referenced.La présente invention concerne un agent pour bloquer « lalimentation en carburant » qui stimule la croissance de cellules cancéreuses en protégeant les cellules environnantes vis-à-vis du cancer, en particulier les cellules fibroblastes stromales. Linvention désactive les produits des cellules environnantes pouvant être utilisés pour la conversion dénergie par la cellule cancéreuse, paralysant ainsi la cellule et désactivant son processus de croissance. Ce
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中国工程科技知识中心
来源网址:
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