Bruno Bujoli;Charlotte Mellier;Pascal Janvier;Ibrahim Khairoun;Verena Schnitzler;Jean-Michel Bouler
发明人:
Bruno Bujoli,Jean-Michel Bouler,Pascal Janvier,Ibrahim Khairoun,Verena Schnitzler,Charlotte Mellier
申请号：
US12716850
公开号：
US08894958B2
申请日:
2010.03.03
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to a galliated calcium-phosphate biomaterial comprising a gallium-doped phosphocalcic compound of formula (I):Ca(10.5-1.5x)Gax(PO4)7 (I)wherein 0<；x<；1 and the salts, hydrates and mixtures thereof and/or a calcium deficient apatite structure with in particular a (Ca+Ga)/P molar ratio in the range of 1.3 to 1.67, and a gallium content up to 4.5% by weight.It also relates to processes of preparation of such materials and uses thereof, in particular as dental or bony implants.It further relates to a kit comprising a galliated calcium-phosphate biomaterial in combination with a fluid component.It finally relates to methods of use of the galliated calcium-phosphate biomaterial, notably for III) ions increase radio-opacity after bone implantation and can be released for inhibiting bone resorption.
