The present invention provides combination therapy methods of treatingproliferative diseases (such as cancer) comprising a first therapy comprisingadministering toan individual an effective amount of a nanoparticle composition (such as anonparticlecomposition of a taxane), and a second therapy which may include, for example,radiation,surgery, administration of chemotherapeutic agents, or combinations thereof.Also providedare methods of administering to an individual a drug (such as a taxane) in ananoparticlecomposition based on a metronomic dosing regime.
