ＮＥＤＤ８－活化酵素之抑制劑农业专利-农业学术服务平台

发明人:: MCCARRON, ASHLEY SUE,马卡龙　艾许莉　苏,馬卡龍　艾許莉　蘇,SELLS, TODD B.,赛尔斯　陶德Ｂ,賽爾斯　陶德Ｂ,STIRLING, MATTHEW,史达林　麦修,史達林　麥修,STROUD, STEPHEN G.,史常德　史蒂芬Ｇ,马卡龙艾许莉苏,馬卡龍艾許莉蘇,赛尔斯陶德B,賽爾斯陶德B,史达林麦修,史達林麥修,史常德史蒂芬G

摘要：: Disclosed are chemical entities which are inhibitors of Nedd8-activating enzyme (NAE), namely, the compound {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyclopentyl}methyl sulfamate and pharmaceutically acceptable salts thereof； solid state forms thereof； and prodrugs thereof. Also disclosed are methods of using the chemical entities to treat disorders such as cancer.本發明揭示作為Nedd8-活化酵素(NAE)之抑制劑之化學實體，即化合物胺磺酸{(1S,2S,4R)-4-[(6-{[(1R,2S)-5-氯-2-甲氧基-2,3-二氫-1H-茚-1-基]胺基}嘧啶-4-基)氧基]-2-羥基環戊基}甲酯及其醫藥上可接受之鹽；其固態形式；及其前藥。本發明亦揭示使用該等化學實體治療諸如癌症等病症之方法。