Provided is a transdermal absorption sheet capable of improving strength against impact at the time of puncture. A transdermal absorption sheet 100 includes a sheet portion 116 and a plurality of needle-like protruding portions 110 arranged on a first principal surface of the sheet portion 116, in which the sheet portion 116 has a center portion 116A which is a region in which the plurality of needle-like protruding portions 110 are formed, and an outer edge portion 116B which is a region from the center portion 116A to an end portion 116C, and a maximum thickness T Max of a thickness portion 116D of the outer edge portion 116B is larger than an average thickness T Ave of the center portion 116A.
