HANKUK UNIVERSITY OF FOREIGN STUDIES RESEARCH ANDINDUSTRY-UNIVERSITY COOPERATION FOUNDATION
发明人:
MYUNG, HEE JOON,명희준,HONG, HYE WON,홍혜원
申请号：
KR1020120016176
公开号：
KR1020130094915A
申请日:
2012.02.17
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: The interaction of NC and Tat is provided to be able to be effectively used as a therapeutic agent target with a purpose of removing the latent state as the interaction causes the Tat reduction, which acts as one factor causing virus latency. CONSTITUTION: The interaction of HIV NC and Tat is provided as an inhibitor target for hindering the latency, based on that the interaction of HIV NC and Tat protein causes the latency. The amount of Tat is reduced by the interaction of HIV NC and Tat protein so that the transcription of HIV is reduced. The transcription level of HIV is controlled according the expression ratio of Tat.본원은 HIV (Human immunodeficiency virus) 바이러스의 복제에 필요한 NC 와 Tat 단백질의 상호작용 및 그를 HIV 치료약물의 표적으로 하는 것에 관한 것이다. 본원의 NC와 Tat의 상호작용은 Tat의 감소를 유발하여 바이러스의 latency(잠복상태)를 일으키는 한 요소로 작용하므로, 이 상호작용은 잠복상태를 제거하는 목적의 치료제 표적으로 효과적으로 사용될 수 있다.
