National Institutes of Biomedical Innovation, Health and Nutrition;SofSera Corporation
发明人:
Ken Ishii,Masayuki Hayashi,Yasumichi Kogai,Daisuke Nomi,Karl Kazushige Kawabe
申请号：
US15761058
公开号：
US20180353598A1
申请日:
2016.09.16
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided is an improved biocompatible immune adjuvant. More specifically, provided are: an immune adjuvant that comprises calcium phosphate, preferably hydroxyapatite, having an average particle size of about 40 nm exclusive to about 1800 nm exclusive； a medicine that comprises this immune adjuvant； and a vaccine that comprises this immune adjuvant. Rod-shaped HAp induced inflammasome-dependent IL-1β production in vitro more strongly than spherical HAp. In WT mice, however, spherical HAp and rod-shaped HAp induced equivalent antigen responses.
