The present invention relates to an intranasal testosterone gel for controlled release of testosterone into the male and female body circulation, to provide a constant effective testosterone blood concentration, without inducing unwanted testosterone spikes in blood concentration, after nasal administration. As such, the intranasal testosterone gel of the present invention is safe, convenient to use, well tolerated, stable, and scaled to make it easy and reproducible, plus, above-normal and below-normal testosterone blood levels Is believed to be kept or avoided to a minimum, and the testosterone serum concentration is kept constant during the administration period, i.e., the intranasal testosterone gel of the present invention mimics testosterone blood concentration to a normal physiological daily physiological testosterone concentration. Or because it recovers, this foot Intranasal testosterone gel in dogs can be tested for male testosterone deficiency, such as low sex drive, impulsive or sexual activity, low fertility, low spermogenesis, sperm amorphism, depression and / or hypogonadism, and female sexual dysfunction, e.g. For example, treating women diagnosed with low sexual desire, impulsive or sexual activity, low one-way responsiveness, low sexual stimulation, sexual desire disorder ("HSDD"), female sexual arousal disorder and / or female orgasmic disorder ("anxiety disorder") For testosterone replacement or supplemental therapy, the present invention also relates to a method for nasally administering intranasal testosterone gels of the invention and a pre-filled multi-dose vacuum applicator system.본 발명은 경비성 투여 후, 혈중 농도에 있어서 원치않는 테스토스테론 스파이크를 유도하지 않으면서, 일정한 유효 테스토스테론 혈중 농도를 제공하기 위해, 남성 및 여성의 체순환에 테스토스테론을 조절방출하기 위한 비내용 테스토스테론 겔에 관한 것으로서, 본 발명의 비내용 테스토스테론 겔은 안전하고, 사용하기에 편리하며, 잘 관용되며, 안정하고, 규모를 증대하여 쉽고 재생가능하게 제조되며, 게다가, 정상-이상 및 정상-이하의 테스토스테론 혈중 농도가 반드시 최소로 유지되거나 피해지는 것으로 믿어지며, 테스토스테론 혈청 농도는 투여기간 동안 반드시 일정하게 유지되는 것으로, 즉 본 발명의 비내용 테스토스테론 겔이 테스토스테론 혈중 농도를 정상의 생리적 1
