G. Mark Anderson,Bernard Scallon,Michael Naso,Ann Cai,Cam Holland
申请号：
US13623144
公开号：
US09708410B2
申请日:
2012.09.20
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Isolated anti-tissue factor antibodies, immunoglobulins, cleavage products and other specified portions and variants thereof having enhanced ADCC activity, as well as anti-tissue factor antibody compositions, encoding or complementary nucleic acids, vectors, host cells, compositions, formulations, devices, transgenic animals, transgenic plants, and methods of making and using thereof. The antibodies of the invention bind human tissue factor and demonstrate enhanced ADCC activity. Accordingly, the antibodies can be used in a variety of methods for diagnosing, treating, and/or preventing diseases involving tissue factor, where enhanced ADCC activity is desirable such as cancer.
