COMPOSITION PHARMACEUTIQUE POUR PRÉVENIR OU TRAITER L'OSTÉOPOROSE À BASE DE DÉRIVÉS DE BENZAMIDINE OU DE SELS DE CEUX-CI, ET D'ACIDE ALENDRONIQUE OU DE SELS DE CELUI-CI
LEE, JIN SOO,HWANG, YUN HA,RYU, JEI MAN,PARK, JAE HOON,CHUNG, DUK KYUN
申请号：
EP09803174
公开号：
EP2307015A4
申请日:
2009.07.31
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
The present invention relates to a pharmaceutical composition for preventing and treating osteoporosis, comprising N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine, 4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine, or salts thereof, and alendronic acid or a salt thereof. As a prophylactic or therapeutic composition for osteoporosis, the combination treatment of N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine, 4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}-benzamidine, or salts thereof and alendronic acid or a salt thereof exhibits excellent inhibitory effect on osteoclast differentiation, as compared to each individual treatment, thereby being useful for the prevention or treatment of osteoporosis.
