Compounds derived from 5 - amino - 4 - 1H pyrazole carboxamide substituted, inhibitors of tyrosine kinase Bruton (BKT); Pharmaceutical Composition and Method for inhibiting the BKT; and Method for treating autoimmune diseases, inflammatory and cancer selected a cell proliferative Disorder Selected B lymphomas.
SPRINGER JOHN ROBERT,DEVADAS BALEKUDRU,GARLAND DANNY JAMES,GRAPPERHAUS MARGARET LANAHAN,HAN SEUNGIL,SELNESS SHAUN RAJ,WALKER DANIEL PATRICK,WAN ZHAO-KUI,XING LI,HOCKERMAN SUSAN LANDIS,HUGHES ROBERT OW
申请号:
CL2015001168
公开号:
CL2015001168A1
申请日:
2015.05.04
申请国别(地区):
CL
年份:
2015
代理人:
摘要:
Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.COMPUESTOS DERIVADOS DE 5-AMINO-1H-PIRAZOL-4-CARBOXAMIDA SUSTITUIDOS, INHIBIDORES DE LA TIROSINA QUINASA DE BRUTON (BTK); COMPOSICIÓN FARMACÉUTICA; Y USO EN EL TRATAMIENTO DE ENFERMEDADES AUTOINMUNES, INFLAMATORIAS, CANCER, TRASTORNOS PROLIFERATIVOS, LINFOMAS.