Transdermal compositions are provided. Aspects of the transdermal compositions include: an active agent layer and a conversion layer, where the conversion layer includes a weak base and, optionally, a carboxylated component. Also provided are methods of using the transdermal compositions and kits containing the transdermal compositions.本發明提供經皮組成物;該等經皮組成物之觀點包括:活性劑層及轉化層,其中該轉化層包含弱鹼及視需要之羧化成分。本發明亦提供使用該等經皮組成物之方法及含該等經皮組成物之套組。