An atherectomy device for removing deposits such as plaque from an interior of a vessel including an outer member (24, 47, 80, 80', 100, 120) and a rotatable shaft (20, 42, 70, 70', 94, 114, 138) positioned for rotational movement within the outer member. The outer member is fixed axially. A rotatable tip (12, 45, 50, 60, 92, 112) is mounted to the distal region of the rotatable shaft for rotation about its longitudinal axis upon rotation of the shaft. The rotatable shaft includes a guidewire lumen (25) for receiving a guidewire (G) to enable over the wire insertion of the device.
