PROBLEM TO BE SOLVED: To provide a composition for making new activation of biofunctions as well as activation of immunological functions, alleviating a sense of fatigue in the aged, and improving the arterial stiffness.SOLUTION: There is provided the composition containing an essence of Cistanche deserticola Y. C. Ma, activating the biofunctions, alleviating the sense of fatigue in the aged, activating the immunological functions, and improving the arterial stiffness.