LEE, SHOEI SHENG,李水盛,SU, MING JAI,苏铭嘉,蘇銘嘉,YEH, CHI HUAN,叶集焕,葉集煥,TSAI, CHENG YEN,蔡政谚,蔡政諺,RUAN, CHI TUN,阮琪惇,LIN, CHIN TING,林敬婷,HSU, CHAO MIN,徐兆民
申请号：
TW103119114
公开号：
TWI531369B
申请日:
2014.05.30
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
The present invention provides a use of an aporphine alkaloid derivative in manufacturing a medication effective in AMP-dependent protein kinase (AMPK) activation, wherein the aporphine alkaloid derivative may be 1,10-dihydroxyaporphine. The medication is able to activate AMPK, and thus is effective in the regulation of cell growth and metabolism, and the treatment of AMPK associated diseases.本發明提供一種阿朴啡生物鹼衍生物用於製備具有活化磷酸化腺苷酸依賴蛋白激酶(AMPK)功效的藥物之用途，其中該阿朴啡生物鹼衍生物可為1,10-二羥基阿朴啡(1,10-dihydroxyaporphine)。其中該藥物可以活化AMPK，因而可用於調節細胞生長及代謝，及治療AMPK相關疾病。
