Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level
Robert M. Jones;James N. Leonard;Zhi-Liang Chu;Hussien A. Al-Shamma
发明人:
Zhi-Liang Chu,James N. Leonard,Hussien A. Al-Shamma,Robert M. Jones
申请号：
US12610639
公开号：
US08198232B2
申请日:
2009.11.02
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention concerns combination of an amount of a GPR119 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the combination provides an effect in lowering a blood glucose level or in increasing a blood GLP-1 level in a subject over that provided by the amount of the GPR119 agonist or the amount of the DPP-IV inhibitor alone and the use of such a combination for treating or preventing diabetes and conditions related thereto or conditions ameliorated by increasing a blood GLP-1 level. The present invention also relates to the use of a G protein-coupled receptor to screen for GLP-1 secretagogues.
