The invention relates to virus like particles (VLP) associated with alysosomal enzyme or anexpression vector encoding a lysosomal enzyme which are used in a method forthetreatment of a lysosomal storage disease. The invention also relates to apharmaceuticalcomposition for use in a method for the treatment of a lysosomal storagedisease, to anexpression vector encoding a lysosomal enzyme and to a method of associating aVLP withan expression vector encoding a lysosomal enzyme.
