LIANG, CONGXIN,KOENIG, MARCEL,HE, YUANJUN,HOLMBERG, PAR
申请号：
CA2681015
公开号：
CA2681015C
申请日:
2008.03.10
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The invention provides inhibitors of focal adhesion kinase, an enzyme involved in the attachment of the cytoskeleton of a cell to an extracellular matrix, which has been implicated in processes such as cell migration, cell proliferation, and cell survival. The inhibitors are derivatives of a 5-substituted 2,4-diaminopyridine wherein the substituents are as defined herein. The invention also provides a method of using the inhibitors in treatment of cancer, and methods of preparation of the inhibitors by use of coupling reactions.
