Methods for Restoring Sensitivity to TTFields in TTFields-Resistant Cancer Cells with PTGER3 Inhibitors

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专利权人:

Novocure GmbH

发明人:

David TRAN,Son Bang LE,Dongjiang CHEN

申请号：

US16832572

公开号：

US20200306531A1

申请日:

2020.03.27

申请国别(地区):

US

年份:

2020

代理人:

摘要：

Methods of reducing the viability of cancer cells, preventing cancer cells of a subject from developing resistance to TTFields, and restoring sensitivity of cancer cells to TTFields by recommending or prescribing a PTGER3 inhibitor to a subject and applying an alternating electric field to the cancer cells are provided. In some instances, sensitivity of cancer cells to TTFields can be restored with one or more PTGER3 inhibitors (e.g., NSAIDs, cox2 inhibitors).

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中国工程科技知识中心

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