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Oxadiazole compounds substituted and their use as S1P1 agonists
专利权人:
BRISTOL-MYERS SQUIBB COMPANY
发明人:
DAS, JAGABANDHU,KO, SOO SUNG
申请号:
ES11764926
公开号:
ES2548258T3
申请日:
2011.09.23
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A compound of formula (I): ** Formula ** or its stereoisomers, N-oxides or salts; wherein: Ring A is phenyl, thiophenyl, thiazolyl, pyridinyl or pyridinonyl; (i) R1 and R2 are -CH3; or (ii) R1 and R2 together with the carbon atom to which they are attached form a C4-6 cycloalkyl substituted with zero at 2 Ra; each R3 is independently: (i) F, Cl, C1-4 alkyl, -CF3, -OCH3, -OCF3 and / or -NH2; and / or (ii) -CH2A1, -OA1, -OCH2A1, -CH2OA1 and / or -CH2SO2A1, wherein A1 is phenyl, pyridinyl, thiazolyl or imidazolyl substituted with zero to 2 substituents independently selected from F, Cl, - NH2, C1-2 alkyl, CF3 and / or -OCH3; L1 is - (CRbRb) 2-4- or - (CH2) 0-2O (CH2) 1-2-; L2 is a link; Q is phenyl substituted with zero to 3 substituents independently selected from F, Cl, -CH3, -CN, and / or -CF3; each Ra is independently F and / or -CH3; and / or two Ra attached to the same carbon atom form>; = O; and each Rb is independently H, -CH3 and / or -OH, with the proviso that if Rb is -OH, then the second Rb attached to the same carbon is not -OH or F; and n is zero, 1, 2 or 3.Un compuesto de fórmula (I): **Fórmula** o sus estereoisómeros, N-óxidos o sales; en la que: El anillo A es fenilo, tiofenilo, tiazolilo, piridinilo o piridinonilo; (i) R1 y R2 son -CH3; o (ii) R1 y R2 junto con el átomo de carbono al que están unidos forman un cicloalquilo C4-6 sustituido con cero a 2 Ra; cada R3 es independientemente: (i) F, Cl, alquilo C1-4, -CF3, -OCH3, -OCF3 y/o -NH2; y/o (ii) -CH2A1, -OA1, -OCH2A1, -CH2OA1 y/o -CH2SO2A1, en donde A1 es fenilo, piridinilo, tiazolilo o imidazolilo sustituido con cero a 2 sustituyentes de manera independiente seleccionados entre F, Cl, -NH2, alquilo C1-2, CF3 y/o -OCH3; L1 es -(CRbRb)2-4- o -(CH2)0-2O(CH2)1-2-; L2 es un enlace; Q es fenilo sustituido con cero a 3 sustituyentes seleccionados independientemente entre F, Cl, -CH3, -CN, y/o -CF3; cada Ra es de manera independiente F y/o -CH3; y/o dos Ra unidos al mismo átomo de carbono forman >;=O;
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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