INSTITUT PASTEUR;INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
发明人:
Pierre Langlade-Demoyen,Fransisco Garcia Pons,Olivier Adotevi,Sylvain Cardinaud,Christine Neuveut
申请号：
US15481452
公开号：
US10767167B2
申请日:
2017.04.06
申请国别(地区):
US
年份:
2020
代理人:
摘要：
This invention relates to the field of anticancer therapy, and to the identification of immunogenic peptides derived from the human telomerase reverse transcriptase (hTERT). The present invention relates to polynucleotides encoding hTERT epitopes restricted to MHC class I molecule, analogues thereof and polyepitopes containing such epitopes and/or analogues. Are also included in the present invention, vector and cell comprising such polynucleotides. The present invention also concerns composition comprising hTERT polypeptides, corresponding polynucleotides, vectors and cells, for use in the treatment and/or prevention of cancer.
