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Compositions and methods of treatment of colitis
专利权人:
АЭРПИО ТЕРАПЬЮТИКС ИНК. (US)
发明人:
ГАРДНЕР Джозеф Х. (US),ШАЛВИЦ Роберт (US)
申请号:
RU2012123388/15
公开号:
RU2012123388A
申请日:
2010.11.05
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. The use of a compound for the manufacture of a medicament for the treatment of an inflammatory disease of epithelial tissue, wherein the compound is a compound of the formula where Z is a group of the formula R is 0 to 5 substituents of hydrogen atoms; the index n is an integer from 0 to 5; L is selected from CH or SO; R and R, each independently selected from i) hydrogen; ii) substituted or unsubstituted CC linear, branched or cyclic alkyl; iii) substituted or unsubstituted CC linear, branched or cyclic alkenyl; iv) substituted or unsubstituted C — C linear or branched alkynyl; v) substituted or unsubstituted Cily Saryl; vi) substituted or unsubstituted C — C heterocyclyl; vii) substituted or unsubstituted C — C heteroaryl; or viii) R and R together can form a substituted or unsubstituted heterocyclic or substituted or unsubstituted heteroaryl ring containing from 2 to 20 carbon atoms and from 1 to 7 heteroatoms; or a pharmaceutically acceptable salt thereof. 2. The use according to claim 1, wherein the compound is in the form of a pharmaceutically acceptable salt selected from the hydrochloride salt, hydrosulfate salt, sulfate salt, p-toluenesulfonyl salt, methanesulfonyl salt and mixtures thereof. The use according to claim 1 or 2, where L represents CH.4. The use according to claim 1 or 2, where L is SO.5. The use according to claim 1 or 2, where R and R together form a cycle of formula 6. The use according to claim 1 or 2, where R and R together form a cycle of formula 7. The use according to claim 1 or 2, wherein R and R together form a cycle selected from pyrrolidin-1-yl, 3-hydroxypyrrolidin-1-yl, 2- (pyridin-2-yl) pyrrolidin-1-yl, 2-methylcarboxypyrrolidin-1. Применение соединения для получения лекарственного средства для лечения воспалительного заболевания эпителиальной ткани, где соединение представляет собой соединение формулыгде Z представляет собой группу формулыR обозначает от 0 до 5 заместителей атомов водорода;индекс n представляет собой целое чис
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