Forbindelse eller et farmasøytisk akseptabelt salt derav som er CETP-inhibitorer, farmasøytisk preparat derav, og anvendelse derav for fremstilling av et medikament for behandling av ateriosklerose.
Ali, Amjad,Napolitano, Joann M,Deng, Qiaolin,Lu, Zhijian,Sinclair, Peter J,Taylor, Gayle E,Thompson, Christopher F,Quraishi, Nazia,Smith, Cameron J,Hunt, Juliane A
申请号：
NO20070607
公开号：
NO339808B1
申请日:
2007.02.01
申请国别(地区):
NO
年份:
2017
代理人:
摘要：
Compounds having the structures of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis: In the compounds of Formula I, B or R 2 is a phenyl group which has an ortho aryl, heterocyclic, benzoheterocyclic or benzocycloalkyl substituent, and one other position on the 5-membered ring has an aromatic, heterocyclic, cycloalkyl, benzoheterocyclic or benzocycloalkyl substituent connected directly to the ring or attached to the ring through a -CH 2 -.
