The present invention relates to the Benzoquinazole ketone compounds of formula (I), for M1 receptors forward direction allosteric modulators and can be related to the disease of M1 receptors, such as Alzheimers disease, schizophrenia, pain disorder or sleep disturbance with what treatment. The invention further relates to the purposes comprising the pharmaceutical composition of the compound and the compound and composition in the treatment receptor-mediated diseases of M1.本發明涉及式(I)的苯并喹唑啉酮化合物,其為M1受體正向變構調節劑並且可以用於治療涉及M1受體的疾病,例如阿爾茨海默氏病、精神分裂症、疼痛障礙或睡眠障礙。本發明還涉及包含該化合物的藥物組合物,以及該化合物和組合物在治療M1受體介導的疾病中的用途。
