Systems and methods for setting one or more parameters for a multi-test-period titration for oral appliance therapy are described herein. A method can include performing a titration for oral appliance therapy during a first test period, identifying a variable associated with the titration performed during the first test period, and setting a parameter for a titration for oral appliance therapy to be performed during a second test period. The parameter can be dependent on the variable associated with the titration performed during the first test period. The method can also include performing the titration for oral appliance therapy during the second test period, and establishing an outcome of oral appliance therapy based on the titrations performed during the first and second test periods.
