In a CD4 + T cell, a complex comprising a dermatogenic complex comprising a Dedicator of cytokinesis 8 (DOCK8) protein, a Mammalian STE20-like kinase 1 (MST1) protein, and an endothelial PAS domain protein 1 (EPAS1) protein Flame model non-human animal.CD4+T細胞において、Dedicator of cytokinesis 8(DOCK8)タンパク質、Mammalian STE20-like kinase 1(MST1)タンパク質及びEndothelial PAS domain protein 1(EPAS1)タンパク質を含む複合体が形成不能となる遺伝子変異を有する、アトピー性皮膚炎モデル非ヒト動物。