Theodore Lee ROTH,Eric SHIFRUT,Alexander MARSON,Cristina Puig SAUS,Antoni RIBAS
申请号：
US16568116
公开号：
US20200000851A1
申请日:
2019.09.11
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-β chain and a heterologous TCR-α chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.
