GARDNER JOSEPH H.,가드너 조셉 에이치,SHALWITZ ROBERT,샬위츠 로버트
申请号：
KR1020127014454
公开号：
KR1020120079846A
申请日:
2010.11.05
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
Disclosed herein are prolyl hydroxylase inhibitors that can stabilize hypoxia inducible factor-1 alpha (HIF-1±), as well as hypoxia inducible factor-2 (HIF-2). Also disclosed herein are pharmaceutical compositions comprising one or more of the disclosed compounds. Yet further disclosed are methods for stimulating the cellular immune response in a mammal such as increasing phagocytosis, for example, prolonging the life of phagocytes, inter alia, kerotyiocytes, neutrophils. As such the disclosed compounds provide methods for treating diseases that relate to the body's immune response.본원에는 대장염 및 여타 염증성 장 질환, 특히 불확정 대장염, 크론씨 병, 과민성 대장 증후군 및 허혈성 대장염의 치료를 위한 조성물 및 방법이 개시된다.
