PHILIPPE DUCHAUSSOY,PIERRE FONS,ALEXANDRE FROIDBISE
申请号：
MX2012001945
公开号：
MX2012001945A
申请日:
2010.08.12
申请国别(地区):
MX
年份:
2012
代理人:
摘要：
The invention relates to FGF receptor-activating N-sulfate oligosaccharides having Formula (I), wherein R1, R4, R6, and R8 are -OSO3- or hydroxyl groups, R2 is an -O-alkyl group or a monosaccharide having Formula (II), R3 is a disaccharide having Formula (III), R5 is a disaccharide having Formula (IV), R7 is a hydroxyl group or a disaccharide having Formula (VI), and R9 is a hydroxyl or -O-alkyl group or a disaccharide having Formula (VII), where R10 is an -O-alkyl group. The invention further relates to the preparation of said oligosaccharides and to the therapeutic use thereof.Oligosacáridos N-sulfatados activadores de los receptores de FGF, que responden a la fórmula (I) en donde R1, R4, R6 y R8 representan grupos -OSO3 o hidroxilo, R2 representa un grupo -O-alquilo o un monosacárido de fórmula de fórmula (II), R3 representa un disacárido de fórmula (III), R5 representa un disacárido de fórmula (IV), R7 representa un grupo hidroxilo o un disacárido de fórmula (VI) R9 representa un grupo hidroxilo u -O-alquilo o un disacárido de fórmula (VII), R10 representa un grupo - O-alquilo Su preparación y su uso en terapéutica.
