COMPOSES HETEROCYCLIQUES SUBSTITUES PAR AMIDE, UTILES COMME MODULATEURS D'IL-12, IL-23 ET/OU DE REPONSES A L'IFN?

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专利权人:

BRISTOL-MYERS SQUIBB COMPANY

发明人:

MOSLIN, RYAN M.,WEINSTEIN, DAVID S.,WROBLESKI, STEPHEN T.,TOKARSKI, JOHN S.,KUMAR, AMIT,BATT, DOUGLAS G.,LIN, SHUQUN,LIU, CHUNJIAN,SPERGEL, STEVEN H.,ZHANG, YANLEI

申请号：

CA2890981

公开号：

CA2890981A1

申请日:

2013.11.07

申请国别(地区):

CA

年份:

2014

代理人:

摘要：

Compounds having the following formula I: or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNa, by acting on Tyk-2 to cause signal transduction inhibition.

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中国工程科技知识中心

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http://www.ckcest.cn/home/