CHO, DER YANG,周德阳,周德陽,CHIU, SHAO CHIH,邱绍智,邱紹智,JAN, CHIA ING,詹佳颖,詹佳穎,PAN, CHIH MING,潘志明,HUANG, SHI WEI,黄士维,黃士維
申请号：
TW107132664
公开号：
TWI694083B
申请日:
2018.09.17
申请国别(地区):
TW
年份:
2020
代理人:
摘要：
The invention relates to a chimeric antigen receptor, an isolated nucleic acid, a chimeric antigen receptor expression plasmid, a chimeric antigen receptor expressing cell, a pharmaceutical composition for treating cancer and a use of the chimeric antigen receptor expressing cell. The chimeric antigen receptor specifically binds to human leukocyte antigen G. The nucleic acid encodes the chimeric antigen receptor. The chimeric antigen receptor expression plasmid expresses the chimeric antigen receptor. The chimeric antigen receptor expressing cell is obtained by transducing the chimeric antigen receptor into an immune cell. The pharmaceutical composition for treating cancer includesthe chimeric antigen receptor expressing cell and a pharmaceutically acceptable carrier. Therefore, the chimeric antigen receptor expressing cell can be used to induce death of mammalian tumor cells.本發明係關於一種嵌合抗原受體、單離的核酸、嵌合抗原受體表達質體、表達嵌合抗原受體細胞、用於治療癌症之醫藥組合物以及表達嵌合抗原受體細胞之用途。嵌合抗原受體與人類白細胞抗原G專一性結合。核酸編碼所述嵌合抗原受體。嵌合抗原受體表達質體可表現所述嵌合抗原受體。表達嵌合抗原受體細胞係將嵌合抗原受體轉導至免疫細胞中而得。用於治療癌症之醫藥組合物，包含表達嵌合抗原受體細胞和醫藥上可接受載劑。藉此，表達嵌合抗原受體細胞可用於誘導哺乳類動物之腫瘤細胞死亡。
