CELLULES SOUCHES HEMATOPOIETIQUES TRAITEES PAR FUCOSYLATION IN VITRO ET PROCEDES POUR LES UTILISER

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专利权人:

MCEVER, RODGER P.;XIA;XIA, LIJUN; LIJUN

发明人:

XIA, LIJUN,MCEVER, RODGER P.

申请号：

CA2522743

公开号：

CA2522743C

申请日:

2004.03.03

申请国别(地区):

CA

年份:

2013

代理人:

摘要：

A method of in vitro fucosylation of selectin ligands on cord blood-derivedhematopoietic stem cells for bone marrow transplantation is disclosed. In thismethod, an effective amount of an .alpha.1,3-fucosyltransferase, e.g.,.alpha.1,3-fucosyltransferase VI, is used in vitro to treat cord blood-derivedhematopoietic stem cells to convert non-functional PSGL-1 or other ligands onthe cell surface into functional forms that bind selectins, especially P-selectin or E-selectin. The treated cells have enhanced effectiveness inreconstituting bone marrow in patients in need of such therapy.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/