MALATE SALT OF N-(4-{[6,7-BIS(METHYLOXY)QUINOLIN-4-YL]OXY}PHENYL)-N'-(4 -FLUOROPHENYL) CYCLOPROPANE-1,1-DICARBOXAMIDE, AND CRYSTALLINE FORMS THEREOF FOR THE TREATMENT OF CANCER
BROWN, Adrian St. Clair,LAMB, Peter,GALLAGHER, William P.
申请号：
AU2016262732
公开号：
AU2016262732B2
申请日:
2016.11.24
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
#$%^&*AU2016262732B220180426.pdf#####MALATE SALT OF N-(4-{[6,7-BIS(METHYLOXY)QUINOLIN-4YL]OXY}PHENYL)-N'-(4-FLUOROPHENYL)CYCLOPROPANE-1,1DICARBOXAMIDE, AND CRYSTALLINE FORMS THEREOF FOR THE TREATMENT OF CANCER ABSTRACT Disclosed are malate salts of N-(4-{ [6,7-bis(methyloxy)-quinolin-4-yl]oxy}phenyl)N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, including a (L)-malate salt, a (D)malate salt, a (DL) malate salt, and mixtures thereof； and crystalline and amorphous forms of the malate salts. Also disclosed are pharmaceutical compositions comprising at least one malate salts of N-(4-{ [6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide； and methods of treating cancer comprising administering at least one malate salt of N-(4-{ [6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N'-(4fluorophenyl)cyclopropane- 1,1 -dicarboxamide. 44
