KERSCHBAUMER, RANDOLF,SCHEIFLINGER, FRIEDRICH,RIEGER, MANFRED,THIELE, MICHAEL,MUDDE, C. GEERT,MUELLBERG, JUERGEN,HOET, RENE
申请号：
HK11101702.4
公开号：
HK1147762B
申请日:
2011.02.21
申请国别(地区):
HK
年份:
2015
代理人:
摘要：
The present application relates to monoclonal antibodies and antigen-binding portions thereof, that specifically bind to the C-terminal or the center region of macrophage migration inhibitory factor (MIF). These anti-MIF antibodies and antigen-binding portions thereof further inhibit human MIF biological function. The application also relates to isolated heavy and light chain immunoglobulins derived from the anti-MIF antibodies and nucleic acid molecules encoding such immunoglobulins. The present application also relates to a method of identifying anti-MIF antibodies, pharmaceutical compositions comprising these antibodies and a method of using these antibodies and compositions for the treatment of MIF-related conditions.
