The present invention relates to a technique for using a malate-aspartate shuttle (MAS) inhibitor as a cancer treatment agent, and more specifically, phenyl succinic acid (MAS) inhibitor, methyl malonic acid (Methyl Malonic Acid). ), N- (1-pyrenyl) maleimide (N- (1-pyrenyl) maleimide) and phthalonic acid (Phthalonic Acid), or a pharmaceutical for the prevention and treatment of cancer containing a mixture of the MAS and anticancer agents as an active ingredient To provide a composition.본 발명은 말산-아스파르트산 왕복수송(malate-aspartate shuttle, MAS) 억제제를 암 치료제로서 사용하는 기술에 관한 것으로, 보다 구체적으로 MAS 억제제인 페닐숙신산(Phenyl Succinic Acid), 메틸말론산(Methyl Malonic Acid), N-(1- 피레닐)말레이미드(N-(1-pyrenyl)maleimide) 및 프탈로닉산(Phthalonic Acid), 또는 상기 MAS 및 항암제의 혼합물을 유효성분으로 함유하는 암 예방 및 치료용 약학적 조성물을 제공한다.
